Comparative sequence analysis of SARS nCoV and SARS CoV genomes for variation in structural proteins

SARS-nCoV was identified as corona virus had spread worldwide very quickly and affected more than million people worldwide. To halt this acceleration for efficient control the knowledge on genomic information is of utmost importance. We attempted to determine nature variation i.e., insertion, deletion, substitution, among structural sequences required code membrane, spike, nucleocapsid, envelope protein glycosylation between SARS CoV nCoV spike glycoproteins, respectively. Comparative sequence analysis performed by using retrieved from NCBI database. The analyzed revealed, that coding show minor substituting amino acids. showed 94.74 percent acid identities with protein. In comparison nCoV, distinct residues vary in proteins, S exhibited one six insertion hundred three substitutions sequence. Insertion valine found receptor binding domain at position 487, NSPR 683–686. Deletions were also nucleotide strain B.1.617.2 nCoV. Additionally, interaction pattern ACE2 original wild-type SARS-CoV-2 recently evolved Omicron variant evaluated. docking results substantiated specific likely impact virulence both variants.